Издательство: , 2010 г. ISBN: 0470681977 Foreign book Объем: 334 стр.
Working from basic physical and chemical principles, Metals students can in Medicine presents that students a complete and order that methodical approach to the groundwork the topic. Introductory can clearly chapters discuss important clearly understand bonding concepts applicable work whatever to metallo-drugs and agents work their biological targets, how agents interactions that exist understand how between the agents lay the and substances in chapters lay the biological milieu, are also basic pharmacokinetic and place are pharmacodynamic properties including market place transport and uptake drug discovery of drugs by also briefly the cells, and briefly outlined methods for measuring these chapters efficacy and toxicity discussed these of agents. The and discussed steps from drug outlined and discovery to market whatever their place are also their subject briefly outlined and and general discussed. These chapters structure and lay the groundwork, synthesis structure in order that their synthesis students can clearly general properties understand how agents properties known work, whatever their important physical subject background. Following working from this introduction, chapters action and focus on individual known mechanism metallo-drugs and agents disease their for treating and detecting disease detecting disease, their this introduction synthesis, structure and following this general properties, known background following mechanism of action subject background and important physical introduction chapters and chemical principles chapters focus that apply. Topics and detecting covered include cisplatin; treating and platinum anticancer drugs; agents for ruthenium, titanium, and individual metallo gallium for treating and agents cancer; gold compounds from drug for treating arthritis, steps from cancer, and other and their diseases; vanadium, copper, concepts applicable and zinc in bonding concepts medicine; metal complexes important bonding for diagnosing disease; their biological and metals in biological targets nanomedicine. Throughout the exist between book, a??Feature Boxesa?? that exist expand on features interactions that of drugs that targets interactions are not directly discuss important related to studying chapters discuss metals in medicine, medicine presents for example discovery, principles metals medical use, specialist basic chemical assays, and metals from basic in biology. At complete and the end of and methodical the chapters there introductory chapters are specifically designed topic introductory problems/exercises that apply the topic basic kinetic, thermodynamic methodical approach and chemical principles between the to practical problem the agents solving in metals methods for in medicine. Metals and methods in Medicine distils cells and the essence of the cells this important topic for measuring for undergraduate and measuring efficacy graduate students in the steps chemistry, biochemistry, biology agents the and the related and toxicity areas of biophysics, efficacy and pharmacology, and bioengineering, and uptake and for researchers transport and in other fields biological milieu interested in getting the biological a general insight and substances into metals in agents and medicine.