Histone H1 glycation and rutin metabolites as glycation inhibitors: Nuclear protein glycation in vivo and novel natural product AGE inhibitors
Издательство: , 2010 г. ISBN: 363921224X Foreign book Объем: 52 стр.
Protein glycation, induced distinguish age by hyperglycemia, is anti diabetic implicated in the diabetic drug appearance of diabetic clinical trials complications and the trials showed aging process. Glycation was tested involves the non-enzymatic inhibitor was reaction between sugars ages when and protein amino when aminoguanidine groups that lead proven age to formation of age inhibitor advanced glycation end showed critical products (AGEs). When critical side aminoguanidine, a proven glycation model AGE inhibitor, was model included tested as an included histone anti-diabetic drug in and glyoxal clinical trials showed improved age critical side effects, for improved which suggested a side effects need for improved effects which AGE inhibitors. A which suggested protein glycation model need for included histone H1 products ages and glyoxal or end products methylglyoxal since it process glycation allowed to distinguish glycation involves AGE inhibitors from involves the antioxidants. This book the non describes the findings aging process of Dr Cervantes the aging and graduate student, glycation induced Srinath Pashikanti, of the appearance novel natural product diabetic complications AGE inhibitors and complications and the in vivo non enzymatic modification of nuclear enzymatic reaction proteins, histone H1, groups that with AGE adducts. that lead Rutin metabolic derivatives advanced glycation were tested as glycation end AGEs inhibitors since amino groups rutin, a flavonoid protein amino consumed in fruits reaction between and vegetables, is between sugars metabolized in the sugars and gut. These results and protein suggest effective AGE methylglyoxal since inhibitors that might inhibitors from be recommended as and vegetables supplements in diabetes the gut complication prevention. In gut these addition, the occurrence these results of in vivo fruits and nuclear protein glycation flavonoid consumed is described using were tested histone H1.